Immunotherapy of Cancer: Success and Failure

We will work with a variety of datasets that describe a molecular view of cells and how they divide. We will learn about the processes that cause cells to become specialized (differentiate) and to give rise to cancer (transform). We will analyze data on genetic mutations in cancer that distinguish tumor cells from normal cells. We will learn how mutations are detected by the immune system and the basis of cancer immunotherapy. Finally we will analyze data on clinical trials of cancer immunotherapy to define the correlates of success in curing the disease. The students are expected to gain an understanding of data that reveals the basics of cell physiology and cancer, how immunotherapies of cancer work and their current limitations.